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Sendic faces allegations that he used company credit cards for personal purchases when he was head of the state oil company ANCAP.
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Uruguays vice president
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"I presented my irrevocable resignation from the vice presidency to the plenary of the Broad Front," the leftist ruling party, Sendic, 55, said on Twitter.
A recent report by party authorities said there was evidence he had used the credit cards in sports, electronics and jewelry stores.
Sendic has denied wrongdoing.
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